Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

Transmission blocking malaria vaccines: Assays and candidates in clinical development.

Stimulated by recent advances in malaria control and increased funding, the elimination of malaria is now considered to be an attainable goal for an increasing number of malaria-endemic regions. This has boosted the interest in transmission-reducing interventions including vaccines that target sexual, sporogenic, and/or mosquito-stage antigens to interrupt malaria transmission (SSM-VIMT). SSM-V...

Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines

A malaria transmission-blocking vaccine would be a critical tool in achieving malaria elimination and eradication. By using chimpanzee adenovirus serotype 63 and modified vaccinia virus Ankara viral vectored vaccines, we investigated whether incorporating two antigens into one vaccine would result in higher transmission-reducing activity than one antigen. We demonstrated that when Pfs25 was adm...

Title: Serological and molecular tools for the evaluation of malaria transmission blocking vaccines SOPHIE

Developing transmission-blocking strategies for malaria control

Analysis of the varied developmental pathways exploited by malarial parasites as they pass through their differing life stages can be challenging [1–3], the parasites often adopting mechanisms that differ from the conventional norms of their eukaryotic hosts. It is, however, these unexpected differences that provide fascination and drive to the basic research scientist and simultaneously expose...

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination. High-titer functional antibodies are required against target antigens to achieve effective transmission-blocking activity. We have fused Pfs25, the leading malaria TBV candidate antigen to IMX313, a molecular adju...